Pegler's career took off in 1933 when he became a nationally syndicated columnist with Scripps-Howard, roared along under the Hearst family, and ended 30 years later under the auspices of a twitchy sect of neo-Nazis and professional racists from the White Citizens Council and the Rev. Billy James Hargis' truly reptilian Christian Crusade. At his peak in the 1930s and 1940s, Pegler was a leading popularizer of one of the most concerted antidemocratic crusades in this country's history: the vicious backlash against the New Deal and the labor movement to which it gave legal protection. This anti-Roosevelt front included the country's major industrialists, anti-Semitic, red-baiting pamphleteers, Congressman Martin Dies' Committee on Un-American Activities, and an assortment of Depression-era demagogues (and men on horseback who conspired with Hitler's agents in this country).

Although Pegler did not turn against Roosevelt until the president's second term, he quickly became a shrill cheerleader for the right's campaign to paint the New Deal's democratic advances as an internationalist Communist plot. Pegler compared union advocates of the closed shop to Hitler's "goose-steppers." (In his view, the greatest threat to the country was the corrupt labor boss; his exposé of a union official's mob connections earned him a Pulitzer in 1941.) By the 1950s, however, Pegler was showing some nostalgia for the Third Reich. His proposal for "smashing" the AF of L and the CIO was for the state to take them over. "Yes, that would be fascism," he wrote. "But I, who detest fascism, see advantages in such fascism."